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مقاله
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Abstract
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Title:
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Evaluation of Combined Association of MCP-2518 And C3 Polymorphisms with Age-Related Macular Degeneration
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Author(s):
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Mohammad Hossein Jabbarpoor Bonyadi, Mortaza Bonyadi, Tahereh Mohammadian, Nikou Fotouhi, Masoud Soheilian , Alireza Javadzadeh, Hamidreza Moein,.
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Presentation Type:
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Oral
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Subject:
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Posterior Segment and Uveitis
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Others:
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Presenting Author:
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Name:
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Mohammadhossein Jabbarpourbonyadi
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Affiliation :(optional)
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Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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E mail:
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mhbonyadi@yahoo.com
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Phone:
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Mobile:
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09144170912
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Purpose:
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This study was planned to evaluate the possibility of combined association of MCP1–2518 and C3 (R102G) single nucleotide polymorphisms with advanced AMD.
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Methods:
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Peripheral blood sample was obtained from enrolled subjects for DNA extraction. MCP1 and C3 rs2230199 polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism.
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Results:
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In this case-control study 392 samples of advanced AMD patients and samples of healthy controls evaluated. Evaluating different genotypic combinations of C3 and MCP1 in AMD and controls were (GGAA 3.9% vs 0.06%; OR=6.35, 95%CI 0.80-50.61, p=0.04 and CGAA 18.9% vs 11.3%; OR=1.82, 95%CI 1.01-3.30, p=0.044). Other combinations with at risk C3 genotypes were not associated significantly with AMD.
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Conclusion:
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There is a strong association between C3 rs2230199 (R102G) and AMD in the Iranian population. Although there was no association of MCP-2518 (rs 1024611) gene with AMD, our study revealed that the at risk genotype of C3 rs2230199 (GG) is associated with advanced AMD only in presence of AA genotype of MCP1 gene.
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Attachment:
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