|
مقاله
|
Abstract
|
|
|
|
Title:
|
Evaluation of C-Reactive Protein and CC-Cytokine Ligand 2 Polymorphism Interaction for Age-related Macular Degeneration
|
|
Author(s):
|
Mohammad Hossein Jabbarpoor Bonyadi; Tahereh Mohammadian ; Mortaza Bonyadi; Masoud Soheilian; Hamidreza Moein; Mehdi Yaseri.
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Posterior Segment and Uveitis
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Mohammadhossein Jabbarpourbonyadi
|
|
Affiliation :(optional)
|
Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
|
|
E mail:
|
mhbonyadi@yahoo.com
|
|
Phone:
|
|
|
Mobile:
|
09144170912
|
|
|
|
|
Purpose:
|
To determine the possible interactional association of high sensitivity CRP levels and CCL2–2518 gene polymorphism with wet AMD and evaluation of their possible interactive role in AMD susceptibility.
|
|
Methods:
|
137 patients with wet type AMD and 161 healthy controls were recruited and examined. Serum samples were assayed for high sensitivity (hs) CRP which was measured with a high-sensitivity assay. Peripheral blood sample was obtained from all subjects for DNA extraction. Polymorphism in CCL2–2518 (rs 1024611) was genotyped using polymerase chain reaction and restriction fragment length polymorphism .
|
|
Results:
|
The genotype and allele frequencies for CCL2 were not found to be significantly different between AMD and normal controls. Regarding Non-GG and Low CRP (CRP≤3mg/dl) as reference group, non GG-high CRP revealed risk ratio of OR=0.53, GG-low CRP combination showed risk ratio of OR=0.63 and GG-high CRP combination showed OR= 0.75 for wet AMD.
|
|
Conclusion:
|
There was no difference in hs CRP and CCL2 (-2518 A/G) genotypes between study groups. Our results showed no synergistic or additive activity between these two factors for wet AMD susceptibility.
|
|
Attachment:
|
|
|