In this study, corticosteroid eye drops (betamethasone 0.1%)was used as a safe medication before surgery to investigate its preventive or reducing effect on postoperative pain compared with a placebo.

In an Academic practice, from January 20014 t0 jajnuary 2015 in Shahid Sadoughi medical University, Yazd, Iran a randomized, double-blind clinical trial, A single drop of betamethasone 0.1% in one eye and placebo drop in the other eye was administrated every hour starting three hours before surgery. In the first and second days after surgery, 0 to 10 verbal numerical rating scales was used to evaluate pain. Also the extent and severity of photophobia, irritation, foreign body sensation and tearing of the eyes were recorded in

The study was conducted on 60 patients (120 eyes).The mean age of patients was 28.23± 6.19 years the mean score of pain intensity on the first day after showed that the pain score is significantly lower in patients treated with betamethasone than those with placebo (p=0.002), but On the second day there was no significant differences in pain score between groups (p=0.055).The score of eye irritation, foreign body sensation and tearing in the betamethasone group was significantly lower than those in placebo group

Betamethasone can reduce the pain after PRK surgery provide the possibility of using it as a safe medication before surgery.