One of the major side effects of laser therapy for retinopathy of prematurity is the myopic shift after several months in premature infants. This study is to investigate the effect of Bevacizumab injection for restricting ROP progression on developing myopic refractions and compare it with myopic shift after laser therapy.

This is a retrospective study compare refraction data of 70 infants who underwent laser therapy with data of 150 infants who received bevacizumab injection for ROP treatment after 6 months follow-up. Infants had gestational age 25 to 34 weeks and birth weight of 580 to 1800 gr.

In the first group that laser therapy was treatment of choice, 132 eyes were underwent refraction after 6 months. They showed 32.6% low hyperopia, 10.8% high hyperopia, 21.7% low myopia and 34.9% moderate and high myopia. In the second group with IVB injection as a treatment of choice, 284 eyes were underwent refraction after 6 months. They demonstrated 73.8% low hyperopia, 1.01% high hyperopia, 10.05% low myopia and 15.13% moderate and high myopia.

Apparently, myopic shift after IVB injection was significantly lower than after laser therapy.