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       XXV Annual Congress of the Iranian Society of Ophthalmology        بـیــست و پنجمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Fibrovascular tissue formation after Intravitreal injection of autologous bone marrow derived Mesenchymal stem cells in patients with retinitis pigmentosa: Clinical trial phase I, safety
Author(s): Leila Satarian1, Ramin Nourinia2, Sare Safi2, Mozhgan Rezaei Kanavi3, Nasser Aghdami4, Hamid Ahmadie2, Hossein Baharvand
Presentation Type: Oral
Subject: Posterior Segment and Uveitis
Others:
Presenting Author:
Name: Ramin Nourinia
Affiliation :(optional) ophthalmic research center, shahid beheshti university of medical sciences
E mail: ramin.retin@gmail.com
Phone: 02122762086
Mobile: 09128249332
Purpose:

To assess the safety of intravitreal bone marrow derived mesenchymal stem cell in patients with advanced retinitis pigmentosa

Methods:

A prospective, Phase I, nonrandomized, open-label study including 3 patients with retinitis pigmentosa. Evaluations including best corrected visual acuity (BCVA), slit-lamp examination, fundus examination, optical coherence tomography (OCT) and electroretinography (ERG) were done before and after intravitreal injection of BMSCs.

Results:

In a series of three patients undergoing MSCs transplantation, the fibrovascular tissue formation in the vitreous cavity and retrolental space, tractional retinal detachment, Iris neovascularization and mature cataract were observed in one patient. However two other patients did not have any adverse effect.

Conclusion:

Intravitreal injection of autologous bone marrow–derived mesenchymal stem cells in eyes with advanced retinitis pigmentosa maybe was associated with adverse events including fibrovascular tissue formation. This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment.

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  - بـیــست و پنجمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران