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مقاله
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Abstract
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Title:
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Evaluation the effect of repeated intra vitreal Bevacizumab injections on corneal endothelium
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Author(s):
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1-Dr Akbar Derakhshan 2-Dr safinejad 3-Dr Eslampor 4- Dr Irandost
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Presentation Type:
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Poster
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Akbar Derakhshan
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Affiliation :(optional)
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Cornea research center
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E mail:
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derakhshana@mums.ac.ir
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Phone:
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38401136
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Mobile:
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09155204131
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Purpose:
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To evaluate the effect of multiple intravitreal Bevacizumab injection on the corneal endothelial cells.
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Methods:
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40 eyes of 40 CRVO patients underwent multiple intravitreal bevacizumab injections monthly (three times). 1.25 mg / 0.1cc bevacizumab injected intravitreally from 3.5 mm posterior to the limbus.All patients evaluated by specular microscopy before injection and one month after third injection.
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Results:
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There was no adverse effect on corneal endothelium after multiple intravitreal bevacizumab injections ( cumulative dose : 3.75 mg ) one month after third injection. There was no statistically significant change in corneal endothelial cell density after bevacizumab injection(CD: P=0.058).cell size did not change significantly after treatment (P=0.07).cell variance and central corneal thickness difference before and after injection was not significant ( CV:0.291 ,CCT: 0.202).
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Conclusion:
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multiple intravitreal bevacizumab injections in cumulative dose 3.75 mg (1.25mg/ 0.1cc ×3) has no daverse effect on corneal endothelial cells
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Attachment:
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4244DR DERAKHSHAN.pptx
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