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مقاله
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Abstract
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Title:
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Effect of oral photochemotherapy (8-methoxypsoralen + UVA) on the electrophysiologic function of retina
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Author(s):
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Nasser Shoeibi,Ahmadreza Taheri, Malihe Nikandish, Arash Omidtabrizi, Nasim Khosravi
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Presentation Type:
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Poster
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Subject:
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Posterior Segment and Uveitis
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Others:
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Presenting Author:
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Name:
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Nasser Shoeibi
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Affiliation :(optional)
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Retina research center, Mashhad University of Medical Sciences
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E mail:
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nshoeibi@gmail.com
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Phone:
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05137636933
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Mobile:
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09155137345
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Purpose:
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Since we had observed electroretinographic (ERG) abnormalities in some patients undergoing photochemotherapy with normal eye examination, we decided to investigate the effects of oral photochemotherapy (8-methoxypsoralen + Ultraviolet-A) on electrophysiologic function of retina
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Methods:
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Patients with vitiligo, psoriasis or eczema were enrolled. Baseline standard ERG was provided with the RETIport32 device. The second ERG was performed 6 months after the first and at least 1 week after the last photochemotherapy session (mean number of sessions: 45 ± 11).
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Results:
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Forty patients were enrolled; 20 of them (mean age: 31.1 ± 12 years) completed the study. The mean rod response b-wave amplitude decreased from 88.9 ± 47.5 to 86.4 ± 36.6 and standard combined response b-wave amplitude decreased from 266.52 to 261.85 µV (p = 0.422 and p = 0.968, respectively) and the standard combined response a-wave amplitude increased from 155.4 ± 40.0 at baseline to 165.1 ± 48.4 in the follow-up ERG (p = 0.092). The mean single-flash cone response a-wave amplitude decreased insignificantly in the follow-up ERG trace (34.5 ± 13.7 and 29 ± 15.4, respectively, p = 0.242). The mean single-flash cone response b-wave amplitude showed an insignificant increase (p = 0.087). The amplitudes of 30-Hz flicker wave and oscillatory potentials did not change significantly in the follow-up ERG (p = 0.551 and p = 0.739, respectively).
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Conclusion:
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Since no significant change in ERG traces was observed, oral photochemotherapy seems safe for retinal electrophysiologic function.
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Attachment:
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