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مقاله
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Abstract
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Title:
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A Large Outbreak of Fulminant Bacterial Endophthalmitis after Intravitreal Injection of Counterfeit Bevacizumab
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Author(s):
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Hamid Ahmadieh, Morteza Entezari, Saeed Karimi, Amir HosseinMahmoodi, Hamid parhisgar, Mehdi Yaseri
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Presentation Type:
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Poster
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Subject:
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Posterior Segment and Uveitis
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Others:
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Presenting Author:
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Name:
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Morteza Entezari
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Affiliation :(optional)
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Ophthalmic Research Center, Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti Medical Sciences, Tehran, Iran
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E mail:
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entmort@hotmail.com
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Phone:
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22816770
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Mobile:
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09121248273
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Purpose:
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To report a large series of patients with acute bacterial endophthalmitis after intravitreal injection of bevacizumab ( IVB) in two eye hospitals.
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Methods:
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Medical records of patients who presented with acute fulminant endophthalmitis in one or two eyes following intravitreal injection of bevacizumab from two separate vials of different batches in two eye hospitals were reviewed.
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Results:
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Twenty eight eyes of 21 patients presented with acute endophthalmitis 12-48 hours after IVB injection . Cultures from the eyes and the vials were positive for E. coli and Citrobacter, each in one of hospitals . All patients were initially treated with topical, intravitreal and systemic antibiotics. Twenty four eyes underwent pars plana vitrectomy.. Best corrected visual acuity (BCVA) was 1.27±0.89 logMAR before IVB injection which decreased to2.80±0.45 LogMAR after presentation of endophthalmitis and 2.12±0.97 logMAR three months after IVB injection . Final visual acuity was no light perception in four eyes.
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Conclusion:
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This large outbreak of E.coli and Citrobacter endophthalmitis occurred after intravitreal injection of a counterfeit bevacizumab. Visual outcomes were very poor.
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Attachment:
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4184poster.pptx
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