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مقاله
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Abstract
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Title:
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Tumor Necrosis Factor Gene Polymorphisms in Advanced Non-exudative Age-related Macular Degeneration
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Author(s):
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Mohammad Hossein Jabbarpoor Bonyadi; Morteza Bonyadi; Hamid Ahmadieh; Nikoo Fotuhi; Nasser Shoeibi; Saeed Saadat; Zakieh Yagubi.
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Presentation Type:
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Poster
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Subject:
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Posterior Segment and Uveitis
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Others:
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Presenting Author:
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Name:
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Mohammadhossein Jabbarpourbonyadi
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Affiliation :(optional)
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Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
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E mail:
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mhbonyadi@yahoo.com
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Phone:
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Mobile:
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09144170912
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Purpose:
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To investigate tumor necrosis factor (TNF)-α gene polymorphisms in advanced dry-type age-related macular degeneration (AMD) in a population from Northeastern Iran.
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Methods:
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In this case-control study, 50 patients with geographic macular atrophy and 73 gender-matched controls were enrolled. Genomic DNA was extracted from the peripheral blood. Polymerase chain reaction was performed to analyze 2 candidate single nucleotide polymorphisms in the TNF- α gene, namely -1031 T/C and -308 G/A.
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Results:
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The distribution of the -1031 T/C genotype was TT, 62%; TC, 36%; CC, 2% in the patients and TT, 60%; TC, 36%; CC, 4% in the controls (P=0.94). Genotype analysis of TNF-α-308 also revealed no significant difference in distribution between patients (GG, 78%; GA, 22%; AA, 0%) and controls (GG, 74%; GA, 23%; AA, 3%) (P=0.51). None of the haplotypes nor alleles of studied TNF-α polymorphisms were significantly associated with advanced dry-type AMD.
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Conclusion:
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The findings of this study show that polymorphisms in the TNF-α gene, do not play an important role in dry-type AMD in the studied population.
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Attachment:
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4172TNF polymorphism in AMD.pptx
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