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       XXV Annual Congress of the Iranian Society of Ophthalmology        بـیــست و پنجمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Determination of the safe dose of intravitreal minocycline in rabbit eyes
Author(s): Khalil Ghasemi Falavarjani MD, Arash Pourhabibi MD, Kaveh Abri Aghdam MD, Hossein Nazari Khanamiri MD, Bagher Hosseini MD, Mehdi Modarres MD, Abdolreza Pazouki MD.
Presentation Type: Oral
Subject: Posterior Segment and Uveitis
Others:
Presenting Author:
Name: Arash Pourhabibi
Affiliation :(optional) Eye research Center, Rassoul Akram Hospital, Iran University of Medical Sciences
E mail: dr.apourhabibi@yahoo.com
Phone: 5553349
Mobile: 09111373329
Purpose:

To evaluate the retinal toxicity of intravitreal minocycline in rabbit eye.

Methods:

Ten New Zealand albino rabbits, weighing between 2 and 3 kg were used for this study. The initial concentration of minocycline (25 mg) was titrated to obtain different concentrations of 1000 μg, 500 μg, 250 μg, 125 μg, and 62.5 μg in 0.1ml. Each concentration was injected into 2 rabbit eyes. For each dose, normal saline was injected in one contralateral eye and the other fellow eye remained non-injected. Electrophysiologic testing was performed before and 4 weeks after injections. The eyes were enucleated 4 weeks after injections and examined using light microscopy.

Results:

The clinical examination was unremarkable after injections. Electroretinography recordings were significantly affected at all doses in at least one of the a or b wave of cone, rod or maximal combined responses. Histopathologic examination revealed severe atrophy, disorganization, and loss of integrity in all retinal layers in all minocycline injected eyes. Contralateral eyes were normal.

Conclusion:

In our study, intravitreal minocycline was toxic to the retina in albino rabbits even at a concentration of 62.5µg/ml.

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  - بـیــست و پنجمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران